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77

Inhibitors & Agonists

1

Peptides

2

Inhibitory Antibodies

3

Natural
Products

7

Recombinant Proteins

2

Isotope-Labeled Compounds

11

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-50940
    AT7519
    5+ Cited Publications

    at7519M

    CDK Apoptosis Cancer
    AT7519 (AT7519M) as a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.
    <em>AT</em>7519
  • HY-50940A
    AT7519 TFA
    5+ Cited Publications

    at7519M TFA

    CDK Cancer
    AT7519 (AT7519M) TFA as a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.
    <em>AT</em>7519 TFA
  • HY-50514
    AT9283
    5 Publications Verification

    JAK Aurora Kinase Bcr-Abl FLT3 Apoptosis Autophagy Cancer
    AT9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A/B, JAK2/3, Abl (T315I) and Flt3 (IC50s ranging from 1 to 30 nM). AT9283 inhibits growth and survival of multiple solid tumors in vitro and in vivo .
    <em>AT</em>9283
  • HY-12059
    AT7867
    4 Publications Verification

    Akt PKA Ribosomal S6 Kinase (RSK) Cancer
    AT7867 is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.
    <em>AT</em>7867
  • HY-50943
    AT7519 Hydrochloride
    5+ Cited Publications

    CDK Apoptosis Cancer
    AT7519 Hydrochloride is a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.
    <em>AT</em>7519 Hydrochloride
  • HY-12059A
    AT7867 dihydrochloride
    4 Publications Verification

    Akt PKA Ribosomal S6 Kinase (RSK) Cancer
    AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.
    <em>AT</em>7867 dihydrochloride
  • HY-16071
    AT13148
    2 Publications Verification

    Akt PKA ROCK Ribosomal S6 Kinase (RSK) Cancer
    AT13148 is an orally active and ATP-competitive, multi-AGC kinase inhibitor with IC50s of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively.
    <em>AT</em>13148
  • HY-112692

    Opioid Receptor Neurological Disease
    AT-121 is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. AT-121 is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects .
    <em>AT</em>-121
  • HY-112692A

    Opioid Receptor Neurological Disease
    AT-121 hydrochloride is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. AT-121 hydrochloride is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects .
    <em>AT</em>-121 hydrochloride
  • HY-112375

    PROTACs Cancer
    AT6 is a PROTAC AT1 analogue, which is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 with highly selectivity to bromodomain (Brd4).
    <em>AT</em>6
  • HY-13988

    PGE synthase Inflammation/Immunology
    AT-56 is a potent, selective and orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS), with an IC50 of 95 μM and Ki of 75 μM. AT-56 could selectively suppress the drowsiness or pain reaction mediated by L-PGDS-catalyzed PGD2 .
    <em>AT</em>-56
  • HY-114426

    Gap Junction Protein Metabolic Disease
    AT-1002, a 6-mer synthetic peptide , is a tight junction regulator and absorption enhancer .
    <em>AT</em>-1002
  • HY-100028
    AT-130
    1 Publications Verification

    AT-130, a phenylpropenamide derivative, is a potent hepatitis B virus (HBV) replication non-nucleoside inhibitor. AT-130 inhibits the viral DNA synthesis with an EC50 of 0.13 μM. AT-130 inhibits both wt and mutant HBVs. AT-130 has anti-HBV activity in hepatoma cells .
    <em>AT</em>-130
  • HY-139165

    SARS-CoV Infection
    AT-9010, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 can inhibit SARS-CoV-2 replication .
    <em>AT</em>-9010
  • HY-124603
    AT791
    2 Publications Verification

    Toll-like Receptor (TLR) Inflammation/Immunology
    AT791 is a potent and orally bioavailable TLR7 and TLR9 inhibitor. AT791 inhibits TLR7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro .
    <em>AT</em>791
  • HY-148877

    HSP HSV HIF/HIF Prolyl-Hydroxylase VEGFR NF-κB ERK Akt FAK Infection Inflammation/Immunology Cancer
    AT-533 is a potent Hsp90 and HSV inhibitor. AT-533 suppresses tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway. AT-533 also inhibits the activation of the downstream pathways, including Akt/mTOR/p70S6K, Erk1/2 and FAK. AT-533 inhibits the tube formation, cell migration, and invasion of human umbilical vein endothelial cells (HUVECs) .
    <em>AT</em>-533
  • HY-101045

    AT-112 is a ketotanserin analogue. AT-112 has hemodynamic effects. AT-112 significantly reduces portal vein branch blood flow and portal vein pressure. AT-112 can be used to study the pathogenesis of portal hypertension .
    <em>AT</em>-112
  • HY-118987

    Opioid Receptor Neurological Disease
    AT-127 is a NOP receptor partial agonist, stimulating NOP/G-protein interaction in a concentration dependent manner .
    <em>AT</em>-127
  • HY-156992

    Opioid Receptor Neurological Disease
    AT-035 is a high affinity and selective NOP agonist .
    <em>AT</em>-035
  • HY-12059B

    Akt Cancer
    AT7867 hydrochloride is a potent and orally active inhibitor of AKT and p70 S6 kinase. AT7867 hydrochloride has anticancer effect .
    <em>AT</em>7867 hydrochloride
  • HY-161348

    Indoleamine 2,3-Dioxygenase (IDO) Cancer
    AT-0174 is an orally active dual inhibitor of IDO1/TDO2 (tryptophan 2,3-dioxygenase-2) with IC50 values of 0.17 and 0.25 μM, respectively. AT-0174 has antitumor activity .
    <em>AT</em>-0174
  • HY-B0268

    at 2266; CI 919

    Bacterial DNA/RNA Synthesis MicroRNA Antibiotic Infection Cancer
    Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing .
    Enoxacin
  • HY-P99483

    at 004; VT 007

    CD20 Cancer
    Blontuvetmab (AT 004)is a caninized CD20 monoclonal antibody. Blontuvetmab can be used for the research of Canine B-cell lymphoma .
    Blontuvetmab
  • HY-14463
    Onalespib
    5+ Cited Publications

    at13387

    HSP Cancer
    Onalespib (AT13387) is a long-acting second-generation Hsp90 inhibitor with a Kd of 0.71 nM.
    Onalespib
  • HY-114426A

    Gap Junction Protein Metabolic Disease
    AT-1002 TFA, a 6-mer synthetic peptide , is a tight junction regulator and absorption enhancer .
    <em>AT</em>-1002 TFA
  • HY-129586

    at-007

    Aldose Reductase Metabolic Disease
    Govorestat (AT-007) is an orally active brain-penetrant aldose reductase inhibitor with an IC50 value of 100 pM. Govorestat has the potential for galactose-1-phosphate uridyl transferase deficiency research .
    Govorestat
  • HY-137958A
    Bemnifosbuvir
    1 Publications Verification

    at-511

    HCV SARS-CoV Infection
    Bemnifosbuvir (AT-511) is a potent and orally active HCV viral replication inhibitor. Bemnifosbuvir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM). Bemnifosbuvir has pangenotypic antiviral activity .
    Bemnifosbuvir
  • HY-139165B

    SARS-CoV Infection
    AT-9010 triethylamine, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 triethylamine can inhibit SARS-CoV-2 replication .
    <em>AT</em>-9010 triethylamine
  • HY-139165A
    AT-9010 tetrasodium
    1 Publications Verification

    SARS-CoV Infection
    AT-9010 tetrasodium, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 tetrasodium can inhibit SARS-CoV-2 replication .
    <em>AT</em>-9010 tetrasodium
  • HY-19437

    at-1727

    Topoisomerase Cancer
    Bimolane (AT-1727), a human topoisomerase II inhibitor, can be used as an anti-neoplastic agent and for the research of psoriasis. Bimolane shows leukemogenic activity and induces multiple types of chromosomal aberrations in human lymphocytes .
    Bimolane
  • HY-10058

    JAK Aurora Kinase Bcr-Abl FLT3 Apoptosis Autophagy Cancer
    AT9283 lactic acid is a multi-targeted kinase inhibitor with potent activity against Aurora A/B, JAK2/3, Abl (T315I) and Flt3 (IC50s ranging from 1 to 30 nM). AT9283 lactic acid inhibits growth and survival of multiple solid tumors in vitro and in vivo .
    <em>AT</em>9283 lactic acid
  • HY-14829B

    at 2101; D-Isofagomine tartrate; Isofagomine tartrate

    Glucosidase Neurological Disease
    Afegostat tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity .
    Afegostat tartrate
  • HY-111397

    NSC 615291; U-77779

    DNA Alkylator/Crosslinker Cancer
    Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity .
    Bizelesin
  • HY-137958
    Bemnifosbuvir hemisulfate
    1 Publications Verification

    at-527

    HCV SARS-CoV Infection
    Bemnifosbuvir hemisulfate (AT-527), a hemisulfate salt of AT-511, a guanosine nucleotide proagent, is a potent and orally active HCV viral replication inhibitor. Bemnifosbuvir hemisulfate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM). Bemnifosbuvir hemisulfate has pangenotypic antiviral activity .
    Bemnifosbuvir hemisulfate
  • HY-147982

    GABA Receptor Neurological Disease
    GABA-AT-IN-1 (Compound 6) is a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor and significantly elevates the mouse brain GABA level. GABA-AT-IN-1 has the ability to cross the BBB and can be used as an anticonvulsant .
    GABA-<em>AT</em>-IN-1
  • HY-10341
    Fasudil Hydrochloride
    Maximum Cited Publications
    15 Publications Verification

    HA-1077 Hydrochloride; at-877 Hydrochloride

    ROCK Calcium Channel Autophagy PKA PKC HIV Cancer
    Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil Hydrochloride is also a potent Ca 2+ channel antagonist and vasodilator .
    Fasudil Hydrochloride
  • HY-B0308

    CI-978; at-4140

    Bacterial Antibiotic Infection
    Sparfloxacin (CI-978) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity .
    Sparfloxacin
  • HY-10341A

    HA-1077; at877

    ROCK Calcium Channel Autophagy PKA PKC Cancer
    Fasudil (HA-1077; AT877) is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil is also a potent Ca 2+ channel antagonist and vasodilator .
    Fasudil
  • HY-111433

    PROTACs Epigenetic Reader Domain Cancer
    BRD4 degrader AT1 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 as a highly selective Brd4 degrader, with a Kd of 44 nM for Brd4 BD2 in cells.
    BRD4 degrader <em>AT</em>1
  • HY-W016586

    at-125; U-42126

    Parasite Infection Cancer
    Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties .
    Acivicin
  • HY-W016586A

    at-125 hydrochloride; U-42126 hydrochloride

    Parasite Infection Cancer
    Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties .
    Acivicin hydrochloride
  • HY-10341C

    HA-1077 dihydrochloride; at-877 dihydrochloride

    Calcium Channel ROCK PKA PKC Autophagy HIV Cancer
    Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil dihydrochloride is also a potent Ca 2+ channel antagonist and vasodilator .
    Fasudil dihydrochloride
  • HY-149257

    JAK STAT Cancer
    HAT-SIL-TG-1&AT is a Janus tyrosine kinase (JAK) inhibitor with antitumor effects. HAT-SIL-TG-1&AT is the hypoxia-activated prodrug, witch inhibits JAK-STAT signaling in tumor tissue. And HAT-SIL-TG-1&AT inhibits HEL cells proliferation and downregulated phosphorylated STAT3/5 under hypoxic conditions .
    HAT-SIL-TG-1&<em>AT</em>
  • HY-113916

    at13387 lactate

    HSP Cancer
    Onalespib lactate is a potent and cross the blood-brain barrier heat-shock-protein-90 (Hsp90) inhibitor with an Kd value of 0.71 nM. Onalespib lactate inhibits the proliferation, survival and migration. Onalespib lactate decreases the expression of EGFR, p-EGFR, AKT, P-AKT, ERK1/2, P-ERK1/2, S6, P-S6 protein. Onalespib lactate shows antitumor activity. Onalespib lactate has the potential for the research of non-small cell lung cancer (NSCLC) .
    Onalespib lactate
  • HY-156597

    at-752 free base

    SARS-CoV Infection
    Arbemnifosbuvir is a nidovirus DdRp-associated nucleotidyltransferase (NiRAN) domain of non-structural protein 12 (nsp12)-interfering drugs. Arbemnifosbuvir can be used for SARS-CoVs infection research .
    Arbemnifosbuvir
  • HY-10341D

    HA-1077 mesylate; at-877 mesylate

    ROCK Calcium Channel Autophagy PKA PKC Cancer
    Fasudil (HA-1077; AT877) mesylate is a nonspecific and orally active RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil mesylate is also a potent Ca 2+ channel antagonist and vasodilator .
    Fasudil mesylate
  • HY-162125

    Angiotensin Receptor Cardiovascular Disease
    AT2 receptor ligand-1(compound 14) is a potent angiotensin AT2 receptor ligand with the Ki 4.9 nM. AT2 receptor ligand-1 shows high stability in microsomes of the sulfonamide ligands .
    <em>AT</em>2 receptor ligand-1
  • HY-15241

    LCQ-195; at9311

    CDK Cancer
    NVP-LCQ195 (AT9311; LCQ195) is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.
    NVP-LCQ195
  • HY-15464
    (R)-(-)-Gossypol
    2 Publications Verification

    at-101; R-(-)-gossypol acetic acid

    Bcl-2 Family Autophagy Cancer
    (R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.
    (R)-(-)-Gossypol
  • HY-B0268A
    Enoxacin hydrate
    1 Publications Verification

    Enoxacin sesquihydrate; at-2266 hydrate; CI-919 hydrate

    Bacterial DNA/RNA Synthesis MicroRNA Antibiotic Infection Cancer
    Enoxacin hydrate (Enoxacin sesquihydrate), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin hydrate is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin hydrate has potent activities against gram-positive and -negative bacteria. Enoxacin hydrate is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing .
    Enoxacin hydrate

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